Supplementary information for my WBC presentation on Candida auris

Welcome to my webpage on my World Biomaterials Congress 2020 presentation:

Here come the fungal superbugs. What are the biomaterials strategies for combatting them?

This post contains information related to my oral presentation at the World Biomaterials Congress 2020.


 

Questions? Contact?

If you have questions or collaborative ideas, please get in touch.

Email: bryan.coad@adelaide.edu.au

Twitter DM: @DrBryanCoad

University Researcher Profile

My Google Scholar profile


Additions & corrections:

After uploading this presentation, I realised that one point which may not have been clear is about the potential applicability of the antifungal surface coating. The covalently-attached antifungal surface coatings would be surface active and best applied to implantable medical devices as a preventative measure, but not as a way of eliminating or breaking up established biofilms when infections have already been established.


References

Reviews of antifungal surface coatings:

The importance of fungal pathogens and antifungal coatings in medical device infections. C Giles; SJ Lamont-Friedrich; TD Michl; HJ Griesser; BR Coad. Biotechnol Adv 2018, 36, 264-280. DOI: 10.1016/j.biotechadv.2017.11.010

Anti-infective Surface Coatings: Design and Therapeutic Promise against Device-Associated Infections. BR Coad; HJ Griesser; AY Peleg; A Traven. PLoS Pathogens 2016, 12, e1005598. DOI: 10.1371/journal.ppat.1005598

Biomaterials surfaces capable of resisting fungal attachment and biofilm formation. BR Coad; SE Kidd; DH Ellis; HJ Griesser. Biotechnol Adv 2014, 32, 296-307. DOI: 10.1016/j.biotechadv.2013.10.015

On the surface of it: the role of materials science in developing antifungal therapies and diagnostics. BR Coad. Microbiology Australia 2015, 36, 71-73. DOI: 10.1071/Ma15024

Peer-reviewed papers on antifungal surface coatings:

Surface coatings with covalently attached anidulafungin and micafungin prevent Candida albicans biofilm formation. J Naderi; C Giles; S Saboohi; HJ Griesser; BR Coad. Journal of Antimicrobial Chemotherapy 2019, 74, 360-364. DOI: 10.1093/jac/dky437

Surface-grafted antimicrobial drugs: Possible misinterpretation of mechanism of action. J Naderi; C Giles; S Saboohi; HJ Griesser; BR Coad. Biointerphases 2018, 13, 06E409. DOI: 10.1116/1.5050043

Plasma activated coatings with dual action against fungi and bacteria. B Akhavan; TD Michl; C Giles; K Ho; L Martin; O Sharifahmadian; SG Wise; BR Coad; N Kumar; HJ Griesser; MM Bilek. Applied Materials Today 2018, 12, 72-84. DOI: 10.1016/j.apmt.2018.04.003

Caspofungin on ARGET-ATRP grafted PHEMA polymers: Enhancement and selectivity of prevention of attachment of Candida albicans. TD Michl; C Giles; P Mocny; K Futrega; MR Doran; HA Klok; HJ Griesser; BR Coad. Biointerphases 2017, 12, 05G602. DOI: 10.1116/1.4986054

Facile single-step bioconjugation of the antifungal agent caspofungin onto material surfaces via an epoxide plasma polymer interlayer. D Michl; C Giles; AT Cross; HJ Griesser; BR Coad. RSC Advances 2017, 7, 27678-27681. DOI: 10.1039/c7ra03897f

Chlorine-rich plasma polymer coating for the prevention of attachment of pathogenic fungal cells onto materials surfaces. SJ Lamont-Friedrich; TD Michl; C Giles; HJ Griesser; BR Coad. Journal of Physics D-Applied Physics 2016, 49, 294001. DOI: 10.1088/0022-3727/49/29/294001

Antifungal coatings by caspofungin immobilization onto biomaterials surfaces via a plasma polymer interlayer. SS Griesser; M Jasieniak; BR Coad; HJ Griesser. Biointerphases 2015, 10, 04A307. DOI: 10.1116/1.4933108

Surface coatings with covalently attached caspofungin are effective in eliminating fungal pathogens. BR Coad; SJ Lamont-Friedrich; L Gwynne; M Jasieniak; SS Griesser; A Traven; AY Peleg; HJ Griesser. Journal of Materials Chemistry B 2015, 3, 8469-8476. DOI: 10.1039/c5tb00961h


Information on this website:

Two new publications on Antifungal Surface Coatings

The Importance of Fungal Pathogens and Antifungal Coatings in Medical Device Infections

Antifungal surfaces go 3D

Where are we heading with anti-infective medical devices?

New ways of thinking about the use of antibiotic drugs

New Publication in Microbiology Australia

University of South Australia to lead international team in combating devastating fungal infections


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Supplementary information for my WBC presentation on biomimetic surfaces

Welcome to my webpage on my World Biomaterials Congress 2020 presentation:

The blind pathogen. Bioinspired and responsive materials for understanding the role of microbial surface sensing in the causes of plant and animal fungal diseases

This post contains information related to my oral presentation at the World Biomaterials Congress 2020.


 Questions? Contact?

If you have questions or collaborative ideas, please get in touch.

Email: bryan.coad@adelaide.edu.au

Twitter DM: @DrBryanCoad

University Researcher Profile

My Google Scholar profile


Additions & corrections:

On slide 3 I showed the microfluidic device from Prof Daniel Irimia, but failed to give his affiliation. Prof Irimia is researcher and Deputy Director at Massachusetts General Hospital and Harvard Medical School, and organiser of the Fungus Olympics, an event in which my lab participated. You can read more about my involvement in the Fungus Olympics here.

slide


References

Published paper on biodegradable materials:

Visualizing Biomaterial Degradation by Candida albicans Using Embedded Luminescent Molecules To Report on Substrate Digestion and Cellular Uptake of Hydrolysate. BR Coad; TD Michl; CA Bader; J Baranger; C Giles; GC Gonçalves; P Nath; SJ Lamont-Friedrich; M Johnsson; HJ Griesser; SE Plush. ACS Applied Bio Materials 2019, 2, 3934-3941. DOI: 10.1021/acsabm.9b00520

Reviews of fungi/plant relationships:

Cell Wall Responses to Biotrophic Fungal Pathogen Invasion. Annual Plant Reviews. J Chowdhury; BR Coad; A Little. 2019, 1001-1030. DOI: 10.1002/9781119312994.apr0634

Perspective on antifungal surface coatings for human health

Anti-infective Surface Coatings: Design and Therapeutic Promise against Device-Associated Infections. BR Coad; HJ Griesser; AY Peleg; A Traven. PLoS Pathogens 2016, 12, e1005598. DOI: 10.1371/journal.ppat.1005598


Information on this website:

Visualizing Biomaterial Degradation by Candida albicans  Blog post on this paper

Blog post on the Fungus Olympics

Live cell imaging video of Blumeria graminis on a biomimetic surface coating

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Best Poster awards at ASBTE conference

Giresser Coad Group

L to R: Hans Griesser, Stephanie Lamont-Friedrich, Lauren Gwynne, Israt Biva, Altaf Hossain, Bryan Coad

Mycology / Surface Interfaces Group (MSIG) members Stephanie-Lamont Friedrich, Lauren Gwynne, and Altaf Hossain won the best poster awards at the recent ISSIB / ASBTE conference in Sydney (April 2015).

This was a fantastic achievement in winning both of the conference poster awards for MSIG researchers. Stephanie and Lauren (co-presenters) won for their poster entitled “Micro-patterned arrays for investigating the contact-killing mechanism of antifungal surfaces” and Altaf won for his poster “Investigation of natural antifungal compounds and surface coatings“.

Congratulations to Steph, Lauren, and Altaf!

 

ASBTE conference 2014

The Australasian Society for Biomaterials and Tissue Engineering Conference (ASBTE) was held in Lorne, Victoria 22nd – 24th April, 2014.

I presented on the relevance and importance of fungal pathogens in the design of implantable antimicrobial biomedical devices.

Highlights of the conference included presentations from researchers who are taking biomaterials from the lab into the clinic such as Dr. Ron Chatelier from Universal Biosensors and Prof. Steven Prawer form the Melbourne Materials Institute talking about development of the bionic eye.

My official duties had me presenting the awards for best poster presentations and re-election to the ASBTE committee.

The conference dinner was also a highlight and the weather in Lorne held out to make for some nice pleasant days.

Jerome, Nico and myself at the conference dinner. (photo credit: Keith McLean)

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A quick break between sessions to take in the scenery and fresh air in Lorne.

ASID conference 2014

The Australasian Society of Infectious Diseases conference was held in Adelaide 26th to 29th March 2014.

I presented a poster entitled “Current Challenges in the Design of Effective Antifungal Surfaces” on behalf of co-authors Sarah Kidd, Stefani Griesser, David Ellis and Hans Griesser.

The aim of my conference attendance was to push the boundaries of interdisciplinary research. I think that bringing materials science research to the attention of clinicians and infectious disease researchers would provide a new perspective on the health problem of infected biomaterials.