Welcome to my webpage on my World Biomaterials Congress 2020 presentation:
Here come the fungal superbugs. What are the biomaterials strategies for combatting them?
This post contains information related to my oral presentation at the World Biomaterials Congress 2020.
If you have questions or collaborative ideas, please get in touch.
Twitter DM: @DrBryanCoad
Additions & corrections:
After uploading this presentation, I realised that one point which may not have been clear is about the potential applicability of the antifungal surface coating. The covalently-attached antifungal surface coatings would be surface active and best applied to implantable medical devices as a preventative measure, but not as a way of eliminating or breaking up established biofilms when infections have already been established.
Reviews of antifungal surface coatings:
The importance of fungal pathogens and antifungal coatings in medical device infections. C Giles; SJ Lamont-Friedrich; TD Michl; HJ Griesser; BR Coad. Biotechnol Adv 2018, 36, 264-280. DOI: 10.1016/j.biotechadv.2017.11.010
Anti-infective Surface Coatings: Design and Therapeutic Promise against Device-Associated Infections. BR Coad; HJ Griesser; AY Peleg; A Traven. PLoS Pathogens 2016, 12, e1005598. DOI: 10.1371/journal.ppat.1005598
Biomaterials surfaces capable of resisting fungal attachment and biofilm formation. BR Coad; SE Kidd; DH Ellis; HJ Griesser. Biotechnol Adv 2014, 32, 296-307. DOI: 10.1016/j.biotechadv.2013.10.015
On the surface of it: the role of materials science in developing antifungal therapies and diagnostics. BR Coad. Microbiology Australia 2015, 36, 71-73. DOI: 10.1071/Ma15024
Peer-reviewed papers on antifungal surface coatings:
Surface coatings with covalently attached anidulafungin and micafungin prevent Candida albicans biofilm formation. J Naderi; C Giles; S Saboohi; HJ Griesser; BR Coad. Journal of Antimicrobial Chemotherapy 2019, 74, 360-364. DOI: 10.1093/jac/dky437
Surface-grafted antimicrobial drugs: Possible misinterpretation of mechanism of action. J Naderi; C Giles; S Saboohi; HJ Griesser; BR Coad. Biointerphases 2018, 13, 06E409. DOI: 10.1116/1.5050043
Plasma activated coatings with dual action against fungi and bacteria. B Akhavan; TD Michl; C Giles; K Ho; L Martin; O Sharifahmadian; SG Wise; BR Coad; N Kumar; HJ Griesser; MM Bilek. Applied Materials Today 2018, 12, 72-84. DOI: 10.1016/j.apmt.2018.04.003
Caspofungin on ARGET-ATRP grafted PHEMA polymers: Enhancement and selectivity of prevention of attachment of Candida albicans. TD Michl; C Giles; P Mocny; K Futrega; MR Doran; HA Klok; HJ Griesser; BR Coad. Biointerphases 2017, 12, 05G602. DOI: 10.1116/1.4986054
Facile single-step bioconjugation of the antifungal agent caspofungin onto material surfaces via an epoxide plasma polymer interlayer. D Michl; C Giles; AT Cross; HJ Griesser; BR Coad. RSC Advances 2017, 7, 27678-27681. DOI: 10.1039/c7ra03897f
Chlorine-rich plasma polymer coating for the prevention of attachment of pathogenic fungal cells onto materials surfaces. SJ Lamont-Friedrich; TD Michl; C Giles; HJ Griesser; BR Coad. Journal of Physics D-Applied Physics 2016, 49, 294001. DOI: 10.1088/0022-3727/49/29/294001
Antifungal coatings by caspofungin immobilization onto biomaterials surfaces via a plasma polymer interlayer. SS Griesser; M Jasieniak; BR Coad; HJ Griesser. Biointerphases 2015, 10, 04A307. DOI: 10.1116/1.4933108
Surface coatings with covalently attached caspofungin are effective in eliminating fungal pathogens. BR Coad; SJ Lamont-Friedrich; L Gwynne; M Jasieniak; SS Griesser; A Traven; AY Peleg; HJ Griesser. Journal of Materials Chemistry B 2015, 3, 8469-8476. DOI: 10.1039/c5tb00961h
Information on this website:
Two new publications on Antifungal Surface Coatings
The Importance of Fungal Pathogens and Antifungal Coatings in Medical Device Infections
Where are we heading with anti-infective medical devices?
New ways of thinking about the use of antibiotic drugs
New Publication in Microbiology Australia
University of South Australia to lead international team in combating devastating fungal infections